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Ultrasonic system for investigation of blood coagulation process

A co-operative project between Kaunas University of Medicine and Ultrasound Institute

The objective of the project

Development of the sensitive ultrasonic method suitable for investigation of an entire blood clotting process, starting from the first minute structural changes.

The necessity to measure

Whole blood coagulation analysis allows to detect clotting deficiencies related to various diseases and to monitor the effect of drugs such as anticoagulants. Multi-channel measurement of the blood coagulation process enables an investigation of the spatial-temporal variations of blood’s properties during the coagulation process.

Ultrasound Institute

Developed method for investigation of an entire blood clotting process and designed multichannel measurement cells for medical applications.

Principle of blood coagulation monitoring

Principle of monitoring is based on measurements of ultrasound velocity:

  • Measurements are performed on-line in small volumes of blood 0.2 ml;
  • Sensitivity and accuracy of measurements deltac<5cm/s;
  • Influence of temperature is eliminated;
  • Experiments were carried out on a few hundreds of volunteers.

Related information

  1. B. Voleišienė, A. Voleišis. Ultrasound velocity measurements in liquid media. Ultragarsas. 2008. Vol. 63. No. 4. P. 7-19. /pdf/
  2. R. Kažys, A. Voleišis, B. Voleišienė, R. Šliteris, L. Mažeika, P. Grybauskas. Ultrasonic multi-channel method for investigation of non-stationary biologic liquids. Ultragarsas. 2003. Vol. 49. Nr. 4. P. 53-57. /pdf/
  3. B. Voleišienė, A. Voleišis, R. Kažys. L. Mažeika, R. Šliteris. Dynamic calibration method for ultrasonic coagulometry. Ultragarsas. 2002. Vol. 44. No. 3. P. 45-49. /pdf/
  4. A. Voleišis, R. Kažys, L. Mažeika, R. Šliteris, B. Voleišienė, P. Grybauskas. Ultrasonic method for the whole blood coagulation analysis. Ultrasonics. 2002. Vol. 40. Issues 1-8. p.101-107. /pdf/
  5. A. Voleišis, R. Kažys, L. Mažeika, R. Šliteris, B. Voleišienė. Ultrasonic method for the whole blood coagulation analysis. Abstract book of conf. “Ultrasonics International 2001”. 2-5 July 2001. Delft, The Netherlands. /Elsevier science.
  6. B. Voleišienė, A. Mongirdienė, A. Voleišis, R. Šliteris. Reference medium for blood coagulation ultrasonic studies. Ultragarsas (Ultrasound). Kaunas: Technologija. 2000. Vol. 34. No.1. P.20-22. /pdf/
  7. A.Voleišis, R.Kažys, L.Mažeika, R.Šliteris, B.Voleišienė. Ultrasonic technique for the investigation of structural properties of biological fluids. Acustica-Acta Acustica. Berlin: EEIG ISSN 1436-7947. Vol. 85. No. 1. 1999. p. 443-444. /pdf/
  8. P.Grybauskas, R.Kažys, L.Mažeika, R.Grybauskienė, A.Mongirdienė, R.Šliteris, B.Voleišienė, A.Voleišis. Issledovanije biologičeskich židkostej ultrazvukovym koagulografom. Biofizika. ISSN: 0006-3509. Vol. 50. No. 3. 2005. p. 550-558.
  9. P.Grybauskas, A.Mongirdienė, R.Kažys, A.Voleišis, R.Šliteris, L. Mažeika, B.Voleišienė. Ultrasonic coagulography. The Scandinavian Journal of Clinical and Laboratory Investigation. ISSN 0036-5513. Vol. 62. No. 236. 2002. p. 106.
  10. A.Voleišis, R.Kažys, L.Mažeika, R.Šliteris, B.Voleišienė. Ultrasonic technique for the investigation of structural properties of biological fluids. J. Acoust. Soc. Amer. Melville: American Institute Physics. ISSN 0001-4966. Vol. 105. No. 2. Pt.2, February 1999. p. 1369-1370. /pdf/
  11. A.Voleišis, R.Šliteris, B.Voleišienė, R.Kažys, L.Mažeika, V.Cicėnas, P.Grybauskas. Application of linear ultrasonic array to investigation of non-homogeneous media. Ultragarsas. 2005. Vol. 57. No. 4. p. 11-17. /pdf/
  12. B.Voleišienė, A.Mongirdienė, A.Voleišis, R.Šliteris. Reference medium for blood coagulation ultrasonic studies. Ultragarsas. 2000. Vol. 34. No. 1. p. 20-22. /pdf/